Carboxyl esterases

 

These enzymes typically catalyze the conversion of an ester into an alcohol and an acid. They include Acetylcholine Esterase that is the molecular target of organophosphate and carbamate insecticides. Other esterases play roles in breaking down or sequestering such insecticides. 

 

Publications:

Mark G Teese, Peter M Campbell; Colin Scott; Karl H Gordon; Adam Southon; Daniel Hovan; Charles Robin; Robyn J Russell; John G Oakeshott (2010) Transcriptional and proteomic analysis of the esterases of the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology 40(1):1-16.

C. Robin, L. M. J. Bardsley, C. Coppin and J. G. Oakeshott (2009) Birth and Death of gene function in the -esterase cluster of Drosophila. Journal of Molecular Evolution (2009) 69: 10-21.

P.M.Campbell*, G.C.de Q.Robin*, L.N.Court, S.J.Dorrian, R.J.Russell, J.G.Oakeshott (2003) Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Insect Molecular Biology 12(5), 459-471.

G.C.deQ.Robin, C. Claudianos, R.J.Russell and J.G.Oakeshott (2000). Reconstructing the Diversification of a-esterases; Comparing the gene clusters of Drosophila buzzatii and D. melanogaster. Journal of Molecular Evolution 51: 149-160

G.C.deQ.Robin, R.J. Russell, D.J. Cutler, J.G. Oakeshott (2000). The Evolution of an a-Esterase Pseudogene Inactivated in the Drosophila melanogaster Lineage.Molecular Biology and Evolution, 17 (4): 563-575.

J.G.Oakeshott, C.Claudianos, R.J.Russell, G.C.Robin (1999). Carboxyl/Cholineesterases: A Case Study in the Evolution of a Successful Multigene Family. Bioessays 21: (12) p1031-1042.

G.C.deQ.Robin, R.J.Russell K.M.Medveczky, and J.G.Oakeshott and R.J.Russell (1996). Duplication and Divergence of the Genes of the Alpha-Esterase Cluster of Drosophila melanogaster. Journal of Molecular Evolution 43: 241-252.

R.J.Russell, G.C.Robin, P.Kostakos, R.D.Newcomb, T.M.Boyce, K.M.Medveczky and J.G.Oakeshott (1996). Molecular Cloning of an Alpha-Esterase Gene Cluster on Chromosome 3R of Drosophila melanogaster. Insect Biochemistry and Molecular Biology 26 No. 3 pp. 235-247.

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Old images representing the pre-genome chromsome walk to the alpha esterase genes, their phylogenetic relationships and then  gene to allozyme  associations.